NOHR Foundation
Funding Biomedical Research into the
Preventions, Treatments, Causes and Cures
of Hearing Loss & Deafness

  • Project to generate transgenic mice that inhibit gene function to investigate whether certain structural genes involved in embryonic development of inner ear hair cells (responsible for hearing and balance) are also involved in formation of supporting cells. (Michael R. Deans, Ph.D., Johns Hopkins University School of Medicine)

  • Genetic study of retinoic acid signaling perturbations during pregnancy that result in congenital inner ear defects. Retinoic acid (a biological derivative of Vitamin A) is important in inner ear development. The project is relevant to creating preventative therapeutic interventions. (Dorothy A. Frenz, Ph.D., New York Medical College)

  • Genetic investigation into using auditory stem cells to replace lost or damaged spiral ganglion neurons, focused on identifying axon guidance cues to hair cells and the auditory brain stem in the developing inner ear. Sensorineural hearing loss results from injury to spiral ganglion neurons. The work is relevant to therapies to treat auditory neuropathy. (Takako Kondo, Ph.D., Indiana University)

  • Study of auditory abilities of mice with either genetically engineered decreased or enhanced medial olivocochlear (MOC) systems in the brain. The project investigates MOC function in hearing in normal and noisy situations, relevant to understanding hearing difficulties of children and older adults in noisy environments. (Amanda M. Lauer, Ph.D., Johns Hopkins University)

  • Electrophysiological project in adults and young children examining how the brain processes speech in quiet and noise. The study is relevant to understanding normal speech-processing development and mechanisms underlying poor speech identification and discrimination. (Brett A. Martin, Ph.D., Graduate Center of the City University of New York)

  • Developmental genetic study of how the sensory hair cells are innervated by afferent nerve fibers that send information from the inner ear to the brain, and by efferent nerve fibers that provide feedback from the brain to the inner ear. The focus is on the time-course of involvement of the nicotine-sensitive acetylcholine receptor. The investigation is relevant to treating hearing deficits caused by developmental malfunctions. (Isabelle Roux, Ph.D., Johns Hopkins University School of Medicine)

Learn More
Since 1988, the National Organization for Hearing Research Foundation has donated $10 million for 520 projects.

Mission Statement
Special Programs
Preventing Hearing Loss
Research & Grants

The National Organization For
Hearing Research Foundation

P.O. Box 421
Narberth, PA 19072
Phone: 610.649.6114

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Any information provided within this Web site is of a general nature and is not specific to any individual. It should not be considered medical advice. Individuals are encouraged to consult an otolaryngologist or other physician for advice related to hearing and hearing disorders.